Questions on Plasma Quality
Is the quality of plasma maintained after treatment?
No influence on complement system, inhibitors of coagulation, or fibrinolysis markers.
Is the quality of coagulations factors maintained after treatment?
- Coagulation factors and activation are only moderately affected (fibrinogen, factor V, VII,XI). They remain with the specifications set by the Council of Europe guidelines.
- Moderate enhanced thrombin time and aPTT.
- Very little effect on the strength of clot formation as assessed by thrombelastometry (Cardigan et al., Transfusion 2009).
What are the parameters that could influence plasma factors content?
There are so many parameters that could influence plasma factors content : the donor (gender, blood group, season, exercise, age, diet), the donation and separation (anticoagulant concentration, activation during aphaeresis or whole blood donation, time between donation and storage), the sampling (sampling site, freezing of samples) and the measurement (test kit lot, detection method, type of test reaction).