On 29th June 2015, a Macopharma lunch symposium took place during the ISBT congress in London, dealing with blood safety and especially with the THERAFLEX MB-Plasma technology, a photodynamic procedure using Methylene Blue and visible light for the inactivation of pathogens in plasma.
About 150 people attended the symposium. During this session, Macopharma shared two major topics with the scientific community: an international prospective clinical study on MB-treated Plasma and the safety profile of THERAFLEX MB-Plasma.
Dr. Hafiz Qureshi from the University Hospitals of Leicester presented the results of a prospective non-interventional study to evaluate the safety of Methylene Blue Plasma. This was an open label, multi-centre, non-controlled, non-randomized, non-interventional study, in 7 hospitals from 4 countries: Belgium, Greece, Spain and the United Kingdom. The aim of this investigation was:
- to gather data on adverse reactions occurring with MB plasma administered in a routine clinical practice environment
- to know more about their characteristics and behaviour, and the possible factors that may influence their presentation and evolution.
Prof. Axel Seltsam from the German Red Cross blood center NSTOB elaborated on the safety profile of THERAFLEX MB-Plasma. He showed that the THERAFLEX MB-Plasma procedure also reduces bacteria including bacterial spores. Moreover, the inactivation capacity of the procedure on viruses can compensate for reduced transparency of the plasma due to lipaemia.
Dr. Denese Marks from the Australian Red Cross Blood Service added information about the inactivation capacity on Dengue viruses. Inactivation of all four DENV types reached the detection limit of the assay already at half the standard illumination dose.
Moderators, namely Prof. Jean-Pierre Allain (Emeritus Professor of Transfusion Medicine at the Department of Hematology at the University of Cambridge in the United Kingdom) and Prof. Olivier Garraud (Senior Consultant, International Affairs, the Institut National de la Transfusion Sanguine (INTS), France) also contributed to the success of the symposium due to high quality questions,various exchanges and experience feedback.
Many thanks to the presenters, moderators and participants of our symposium on blood safety!
Click here to get access to the abstract book