Picto_Plasma FAQ

 

Questions on Toxicity

What dose of Methylene Blue is used in the Plasma PR Process ?

The dose of Methylene Blue used in the process is 85µg (0,085mg) and is further reduced by filtration (Blueflex filter) during the process with an efficiency of > 90%.

Outcomes on genotoxicity?

No toxic effects in the concentrations used with a high safety margin.

Any contraindications for MB treatment?

There is no contraindications with other treatments. Treated plasma should not be used for patients with known allergies against MB or photoproducts or with a known Glucose-6 phosphate dehydrogenase deficiency.

Are there any recommendations for pregnant women or newborn children?

In the UK the usage of MB-treated plasma is recommended for patients younger than 16 years old. The description can be found in the « Guidelines of the Blood Transfusion Services in the UK 2005 chapter 8.14 « Fresh frozen plasma, methylene blue-treated and removed, leukocyte depleted » and 8.24 « Fresh frozen plasma, neonatal use, methylene blue-treated and removed, leukocyte depleted ». Today there are no recommendations for pregnant women. In Belgium MB plasma is used for all therapeutic indications, also for pregnant women.

Any allergic reactions after transfusion?

Allergic reactions after transfusion of blood components are very common. Mild reactions with localized urticarial rashes have been reported with a ratio between 1 and 3 %. These moderate allergic reactions are only inconvenient for the patient without any threat. (Allergic transfusion reactions statement on september 2010 S. Reichenberg).

Where is Methylene Blue also used ?

Methylene Blue is mainly used as an important Antidot (Antitoxin) against Cyanides and Carbon Monoxid poisoning (e.g. Thermal gas heaters).